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Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances

Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
, 
Anna Aleksandrovna Efimova 1
Anna Aleksandrovna Efimova
, 
Fedor Dmitrievich Mulashkin 1
Fedor Dmitrievich Mulashkin
, 
Galina Nikolaevna Rudenskaya 1
Galina Nikolaevna Rudenskaya
, 
10.1016/j.mencom.2018.03.009
Published 2018-03-01
Communication , Volume 28, Issue 2, 140-142
16
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Yaroslavov A. A. et al. Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances // Mendeleev Communications. 2018. Vol. 28. No. 2. pp. 140-142.
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Yaroslavov A. A., Efimova A. A., Mulashkin F. D., Rudenskaya G. N., Krivtsov G. G. Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances // Mendeleev Communications. 2018. Vol. 28. No. 2. pp. 140-142.
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TY - JOUR
DO - 10.1016/j.mencom.2018.03.009
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.03.009
TI - Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances
T2 - Mendeleev Communications
AU - Yaroslavov, Aleksandr Anatol'evich
AU - Efimova, Anna Aleksandrovna
AU - Mulashkin, Fedor Dmitrievich
AU - Rudenskaya, Galina Nikolaevna
AU - Krivtsov, Georgii Georgievich
PY - 2018
DA - 2018/03/01
PB - Mendeleev Communications
SP - 140-142
IS - 2
VL - 28
ER -
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@article{2018_Yaroslavov,
author = {Aleksandr Anatol'evich Yaroslavov and Anna Aleksandrovna Efimova and Fedor Dmitrievich Mulashkin and Galina Nikolaevna Rudenskaya and Georgii Georgievich Krivtsov},
title = {Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.03.009},
number = {2},
pages = {140--142},
doi = {10.1016/j.mencom.2018.03.009}
}
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Cite this
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Yaroslavov, Aleksandr Anatol'evich, et al. “Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances.” Mendeleev Communications, vol. 28, no. 2, Mar. 2018, pp. 140-142. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.03.009.

Abstract

Multi-liposomal containers were prepared via electrostatic adsorption of 50 nm anionic liposomes on the surface of cationic chitosan nanoparticles (nanogels) 270 nm in diameter. The containers are stable in aqueous-salt solutions but degrade in the presence of proteolytic enzymes down to 10–15 nm particles and release water-soluble substances encapsulated into the adsorbed liposomes. Based on the kinetic data, the mechanism of the release is discussed.

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