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DBU as a scaffold for the synthesis of [1,3]oxazolo[2’,3’ : 2,3]pyrimido-[1,2-a]azepines: annulation with aromatic cyanopropargylic alcohols

Olesya Aleksandrovna Shemyakina 1
Olesya Aleksandrovna Shemyakina
, 
Ol'ga Gennad'evna Volostnykh 1
Ol'ga Gennad'evna Volostnykh
, 
Anton Victorovich Stepanov 1
Anton Victorovich Stepanov
, 
Anastasiya Grigor'evna Mal'kina 1
Anastasiya Grigor'evna Mal'kina
, 
Igor Alekseevich Ushakov 1
Igor Alekseevich Ushakov
, 
Konstantin A Apartsin 2, 3
Konstantin A Apartsin
, 
Victoriya Vladimirovna Kireeva 3
Victoriya Vladimirovna Kireeva
, 
Boris Aleksandrovich Trofimov 1
Boris Aleksandrovich Trofimov
2 Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russian Federation
3 Biomedical Research and Technology Department of the Irkutsk Scientific Center, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation
10.1016/j.mencom.2018.03.004
Published 2018-03-01
Communication , Volume 28, Issue 2, 128-130
9
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Shemyakina O. A. et al. DBU as a scaffold for the synthesis of [1,3]oxazolo[2’,3’ : 2,3]pyrimido-[1,2-a]azepines: annulation with aromatic cyanopropargylic alcohols // Mendeleev Communications. 2018. Vol. 28. No. 2. pp. 128-130.
GOST all authors (up to 50) Copy
Shemyakina O. A., Volostnykh O. G., Stepanov A. V., Mal'kina A. G., Ushakov I. A., Apartsin K. A., Kireeva V. V., Trofimov B. A. DBU as a scaffold for the synthesis of [1,3]oxazolo[2’,3’ : 2,3]pyrimido-[1,2-a]azepines: annulation with aromatic cyanopropargylic alcohols // Mendeleev Communications. 2018. Vol. 28. No. 2. pp. 128-130.
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TY - JOUR
DO - 10.1016/j.mencom.2018.03.004
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.03.004
TI - DBU as a scaffold for the synthesis of [1,3]oxazolo[2’,3’ : 2,3]pyrimido-[1,2-a]azepines: annulation with aromatic cyanopropargylic alcohols
T2 - Mendeleev Communications
AU - Shemyakina, Olesya Aleksandrovna
AU - Volostnykh, Ol'ga Gennad'evna
AU - Stepanov, Anton Victorovich
AU - Mal'kina, Anastasiya Grigor'evna
AU - Ushakov, Igor Alekseevich
AU - Apartsin, Konstantin A
AU - Kireeva, Victoriya Vladimirovna
AU - Trofimov, Boris Aleksandrovich
PY - 2018
DA - 2018/03/01
PB - Mendeleev Communications
SP - 128-130
IS - 2
VL - 28
ER -
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@article{2018_Shemyakina,
author = {Olesya Aleksandrovna Shemyakina and Ol'ga Gennad'evna Volostnykh and Anton Victorovich Stepanov and Anastasiya Grigor'evna Mal'kina and Igor Alekseevich Ushakov and Konstantin A Apartsin and Victoriya Vladimirovna Kireeva and Boris Aleksandrovich Trofimov},
title = {DBU as a scaffold for the synthesis of [1,3]oxazolo[2’,3’ : 2,3]pyrimido-[1,2-a]azepines: annulation with aromatic cyanopropargylic alcohols},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.03.004},
number = {2},
pages = {128--130},
doi = {10.1016/j.mencom.2018.03.004}
}
MLA
Cite this
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Shemyakina, Olesya Aleksandrovna, et al. “DBU as a scaffold for the synthesis of [1,3]oxazolo[2’,3’ : 2,3]pyrimido-[1,2-a]azepines: annulation with aromatic cyanopropargylic alcohols.” Mendeleev Communications, vol. 28, no. 2, Mar. 2018, pp. 128-130. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2018.03.004.

Abstract

Organic superbase DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene, readily annulated with aromatic cyanopropargylic alcohols nder mild conditions (CH2Cl2, 20–25 °C, 30 min) to afford new cyanomethylideneperhydro[1,3]oxazolo[2’,3’:2,3]pyrimido-,2-a]azepines.

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