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Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate

Olesya Olegovna Koloskova 1, 2
Olesya Olegovna Koloskova
, 
Anastasia S Nosova 1, 2
Anastasia S Nosova
, 
Inga Sergeevna Shchelik 2
Inga Sergeevna Shchelik
, 
Igor Petrovich Shilovskiy 1
Igor Petrovich Shilovskiy
, 
Yurii Lvovich Sebyakin 2
Yurii Lvovich Sebyakin
, 
1 State Research Center 'Institute of Immunology', Federal Medico-Biological Agency, Moscow, Russian Federation
10.1016/j.mencom.2017.11.030
Published 2017-10-30
Communication , Volume 27, Issue 6, 626-627
8
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Koloskova O. O. et al. Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 626-627.
GOST all authors (up to 50) Copy
Koloskova O. O., Nosova A. S., Shchelik I. S., Shilovskiy I. P., Sebyakin Y. L., Khaitov M. R. Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 626-627.
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TY - JOUR
DO - 10.1016/j.mencom.2017.11.030
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.030
TI - Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate
T2 - Mendeleev Communications
AU - Koloskova, Olesya Olegovna
AU - Nosova, Anastasia S
AU - Shchelik, Inga Sergeevna
AU - Shilovskiy, Igor Petrovich
AU - Sebyakin, Yurii Lvovich
AU - Khaitov, Musa R
PY - 2017
DA - 2017/10/30
PB - Mendeleev Communications
SP - 626-627
IS - 6
VL - 27
ER -
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@article{2017_Koloskova,
author = {Olesya Olegovna Koloskova and Anastasia S Nosova and Inga Sergeevna Shchelik and Igor Petrovich Shilovskiy and Yurii Lvovich Sebyakin and Musa R Khaitov},
title = {Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate},
journal = {Mendeleev Communications},
year = {2017},
volume = {27},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.030},
number = {6},
pages = {626--627},
doi = {10.1016/j.mencom.2017.11.030}
}
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Koloskova, Olesya Olegovna, et al. “Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate.” Mendeleev Communications, vol. 27, no. 6, Oct. 2017, pp. 626-627. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.030.

Abstract

A drug delivery system based on liposomes has been modified by targeted vectors based on a glycoconjugate, and the vector structure has been optimized. The glycoconjugate in liposomes almost fourfold increases the transfection efficiency of the delivery system in specific human liver cell line (HepG2) in comparison with that of unmodified lipopeptide-based liposomes.

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