Home / Publications / ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold

‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold

, 
Fedor Vladimirovich Ryzhkov 1
Fedor Vladimirovich Ryzhkov
, 
Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
, 
Alexander Dmitrievich Korshunov 1
Alexander Dmitrievich Korshunov
, 
Roman Aleksandrovich Novikov 1
Roman Aleksandrovich Novikov
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.1016/j.mencom.2017.11.006
Published 2017-10-30
Communication , Volume 27, Issue 6, 559-561
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Elinson M. N. et al. ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 559-561.
GOST all authors (up to 50) Copy
Elinson M. N., Ryzhkov F. V., Vereshchagin A. N., Korshunov A. D., Novikov R. A., Egorov M. P. ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 559-561.
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TY - JOUR
DO - 10.1016/j.mencom.2017.11.006
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.006
TI - ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold
T2 - Mendeleev Communications
AU - Elinson, Michail Nikolaevich
AU - Ryzhkov, Fedor Vladimirovich
AU - Vereshchagin, Anatoly Nikolaevich
AU - Korshunov, Alexander Dmitrievich
AU - Novikov, Roman Aleksandrovich
AU - Egorov, Mikhail Petrovich
PY - 2017
DA - 2017/10/30
PB - Mendeleev Communications
SP - 559-561
IS - 6
VL - 27
ER -
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@article{2017_Elinson,
author = {Michail Nikolaevich Elinson and Fedor Vladimirovich Ryzhkov and Anatoly Nikolaevich Vereshchagin and Alexander Dmitrievich Korshunov and Roman Aleksandrovich Novikov and Mikhail Petrovich Egorov},
title = {‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold},
journal = {Mendeleev Communications},
year = {2017},
volume = {27},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.006},
number = {6},
pages = {559--561},
doi = {10.1016/j.mencom.2017.11.006}
}
MLA
Cite this
MLA Copy
Elinson, Michail Nikolaevich, et al. “‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold.” Mendeleev Communications, vol. 27, no. 6, Oct. 2017, pp. 559-561. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.006.

Abstract

Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82–99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.

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