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Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids

Dmitry Andreevich Gruzdev 1
Dmitry Andreevich Gruzdev
, 
Evgeny Nikolaevich Chulakov 1
Evgeny Nikolaevich Chulakov
, 
Galina L'vovna Levit 1
Galina L'vovna Levit
, 
Marionella Anatol'evna Kravchenko 2
Marionella Anatol'evna Kravchenko
, 
Victor Pavlovich Krasnov 1
Victor Pavlovich Krasnov
, 
10.1016/j.mencom.2017.11.002
Published 2017-10-30
Communication , Volume 27, Issue 6, 547-549
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Gruzdev D. A. et al. Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 547-549.
GOST all authors (up to 50) Copy
Gruzdev D. A., Chulakov E. N., Levit G. L., Kravchenko M. A., Krasnov V. P., Charushin V. N. Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids // Mendeleev Communications. 2017. Vol. 27. No. 6. pp. 547-549.
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TY - JOUR
DO - 10.1016/j.mencom.2017.11.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.002
TI - Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids
T2 - Mendeleev Communications
AU - Gruzdev, Dmitry Andreevich
AU - Chulakov, Evgeny Nikolaevich
AU - Levit, Galina L'vovna
AU - Kravchenko, Marionella Anatol'evna
AU - Krasnov, Victor Pavlovich
AU - Charushin, Valery Nikolaevich
PY - 2017
DA - 2017/10/30
PB - Mendeleev Communications
SP - 547-549
IS - 6
VL - 27
ER -
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@article{2017_Gruzdev,
author = {Dmitry Andreevich Gruzdev and Evgeny Nikolaevich Chulakov and Galina L'vovna Levit and Marionella Anatol'evna Kravchenko and Victor Pavlovich Krasnov and Valery Nikolaevich Charushin},
title = {Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids},
journal = {Mendeleev Communications},
year = {2017},
volume = {27},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.002},
number = {6},
pages = {547--549},
doi = {10.1016/j.mencom.2017.11.002}
}
MLA
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MLA Copy
Gruzdev, Dmitry Andreevich, et al. “Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids.” Mendeleev Communications, vol. 27, no. 6, Oct. 2017, pp. 547-549. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.11.002.

Abstract

Novel purine and 2-aminopurine conjugates containing fragments of (S)-aspartic and (S)-glutamic acids with free α-functional groups attached via a 1,2-ethylenediamine linker at 6-position of the purine core, as well as their analogues with N9-(2-hydroxyethoxy)methyl substituent have been synthesized. Among the conjugates obtained, compounds exhibiting a significant antimycobacterial activity have been found.

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