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Cinnamic acid derivatives as the potential modulators of prion aggregation

Sofia Andreevna Tishina 1
Sofia Andreevna Tishina
, 
Viktor Sergeevich Stroylov 2
Viktor Sergeevich Stroylov
, 
Ivan Andreevich Zanyatkin 1
Ivan Andreevich Zanyatkin
, 
Aleksandra Kirillovna Melnikova 1
Aleksandra Kirillovna Melnikova
, 
Vladimir Izrailevich Muronetz 1, 3
Vladimir Izrailevich Muronetz
, 
Yulia Yur'evna Stroylova 3, 4
Yulia Yur'evna Stroylova
10.1016/j.mencom.2017.09.021
Published 2017-09-07
Communication , Volume 27, Issue 5, 493-494
7
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Tishina S. A. et al. Cinnamic acid derivatives as the potential modulators of prion aggregation // Mendeleev Communications. 2017. Vol. 27. No. 5. pp. 493-494.
GOST all authors (up to 50) Copy
Tishina S. A., Stroylov V. S., Zanyatkin I. A., Melnikova A. K., Muronetz V. I., Stroylova Y. Y. Cinnamic acid derivatives as the potential modulators of prion aggregation // Mendeleev Communications. 2017. Vol. 27. No. 5. pp. 493-494.
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TY - JOUR
DO - 10.1016/j.mencom.2017.09.021
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.09.021
TI - Cinnamic acid derivatives as the potential modulators of prion aggregation
T2 - Mendeleev Communications
AU - Tishina, Sofia Andreevna
AU - Stroylov, Viktor Sergeevich
AU - Zanyatkin, Ivan Andreevich
AU - Melnikova, Aleksandra Kirillovna
AU - Muronetz, Vladimir Izrailevich
AU - Stroylova, Yulia Yur'evna
PY - 2017
DA - 2017/09/07
PB - Mendeleev Communications
SP - 493-494
IS - 5
VL - 27
ER -
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@article{2017_Tishina,
author = {Sofia Andreevna Tishina and Viktor Sergeevich Stroylov and Ivan Andreevich Zanyatkin and Aleksandra Kirillovna Melnikova and Vladimir Izrailevich Muronetz and Yulia Yur'evna Stroylova},
title = {Cinnamic acid derivatives as the potential modulators of prion aggregation},
journal = {Mendeleev Communications},
year = {2017},
volume = {27},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.09.021},
number = {5},
pages = {493--494},
doi = {10.1016/j.mencom.2017.09.021}
}
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Tishina, Sofia Andreevna, et al. “Cinnamic acid derivatives as the potential modulators of prion aggregation.” Mendeleev Communications, vol. 27, no. 5, Sep. 2017, pp. 493-494. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.09.021.

Abstract

Eight cinnamic acid derivatives were studied as prion inhibitors in vitro and their cytotoxicity was evaluated. Ferulic (3-methoxy-4-hydroxycinnamic) acid, 3,4,5-trimethoxycin- namic acid and methyl 3-ethoxy-4-acetamidoxycinnamate were found to inhibit amyloid fibril formation, seeding, and spontaneous aggregation of recombinant ovine prion protein. None of the compounds demonstrated cytotoxicity on human neuroblastoma SH-SY5Y cells.

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