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An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship

Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
, 
Anna Aleksandrovna Efimova 1
Anna Aleksandrovna Efimova
, 
Galina Nikolaevna Rudenskaya 1
Galina Nikolaevna Rudenskaya
, 
Nikolay Sergeevich Melik-Nubarov 1
Nikolay Sergeevich Melik-Nubarov
, 
Irina Dmitrievna Grozdova 1
Irina Dmitrievna Grozdova
, 
Alexander Anatol'evich Ezhov 2
Alexander Anatol'evich Ezhov
, 
Sergei Nikolaevich Chvalun 3
Sergei Nikolaevich Chvalun
, 
Alevtina Igorevna Kulebyakina 3
Alevtina Igorevna Kulebyakina
, 
Ekaterina Vladimirovna Kuznetsova 3
Ekaterina Vladimirovna Kuznetsova
10.1016/j.mencom.2017.05.028
Published 2017-04-25
Communication , Volume 27, Issue 3, 299-301
8
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Yaroslavov A. A. et al. An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship // Mendeleev Communications. 2017. Vol. 27. No. 3. pp. 299-301.
GOST all authors (up to 50) Copy
Yaroslavov A. A., Efimova A. A., Rudenskaya G. N., Melik-Nubarov N. S., Grozdova I. D., Ezhov A. A., Chvalun S. N., Kulebyakina A. I., Kuznetsova E. V. An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship // Mendeleev Communications. 2017. Vol. 27. No. 3. pp. 299-301.
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TY - JOUR
DO - 10.1016/j.mencom.2017.05.028
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.05.028
TI - An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship
T2 - Mendeleev Communications
AU - Yaroslavov, Aleksandr Anatol'evich
AU - Efimova, Anna Aleksandrovna
AU - Rudenskaya, Galina Nikolaevna
AU - Melik-Nubarov, Nikolay Sergeevich
AU - Grozdova, Irina Dmitrievna
AU - Ezhov, Alexander Anatol'evich
AU - Chvalun, Sergei Nikolaevich
AU - Kulebyakina, Alevtina Igorevna
AU - Kuznetsova, Ekaterina Vladimirovna
PY - 2017
DA - 2017/04/25
PB - Mendeleev Communications
SP - 299-301
IS - 3
VL - 27
ER -
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@article{2017_Yaroslavov,
author = {Aleksandr Anatol'evich Yaroslavov and Anna Aleksandrovna Efimova and Galina Nikolaevna Rudenskaya and Nikolay Sergeevich Melik-Nubarov and Irina Dmitrievna Grozdova and Alexander Anatol'evich Ezhov and Sergei Nikolaevich Chvalun and Alevtina Igorevna Kulebyakina and Ekaterina Vladimirovna Kuznetsova},
title = {An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship},
journal = {Mendeleev Communications},
year = {2017},
volume = {27},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.05.028},
number = {3},
pages = {299--301},
doi = {10.1016/j.mencom.2017.05.028}
}
MLA
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Yaroslavov, Aleksandr Anatol'evich, et al. “An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship.” Mendeleev Communications, vol. 27, no. 3, Apr. 2017, pp. 299-301. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.05.028.

Abstract

A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after incorporation into the ternary complex. The incubation of cells with the Dox-loaded ternary complex leads to its penetration into the cells, the release of Dox from liposomes and predominant drug accumulation in cell nuclei. The ternary complex degrades to nanoparticles in the presence of proteolytic enzymes to produce low-toxic digestion products.

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