Home / Publications / Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity

Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity

Victoria Vadimovna Abzianidze 1
Victoria Vadimovna Abzianidze
, 
Ksenia P Bolshakova 2
Ksenia P Bolshakova
, 
Daria Stanislavovna Prokofieva 1
Daria Stanislavovna Prokofieva
, 
Alexander Olegovich Berestetskiy 3
Alexander Olegovich Berestetskiy
, 
Victor Anatol'evich Kuznetsov 1
Victor Anatol'evich Kuznetsov
, 
Yury Georgievich Trishin 2
Yury Georgievich Trishin
10.1016/j.mencom.2017.01.026
Published 2016-12-29
Communication , Volume 27, Issue 1, 82-84
8
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Abzianidze V. V. et al. Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity // Mendeleev Communications. 2016. Vol. 27. No. 1. pp. 82-84.
GOST all authors (up to 50) Copy
Abzianidze V. V., Bolshakova K. P., Prokofieva D. S., Berestetskiy A. O., Kuznetsov V. A., Trishin Y. G. Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity // Mendeleev Communications. 2016. Vol. 27. No. 1. pp. 82-84.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2017.01.026
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.01.026
TI - Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity
T2 - Mendeleev Communications
AU - Abzianidze, Victoria Vadimovna
AU - Bolshakova, Ksenia P
AU - Prokofieva, Daria Stanislavovna
AU - Berestetskiy, Alexander Olegovich
AU - Kuznetsov, Victor Anatol'evich
AU - Trishin, Yury Georgievich
PY - 2016
DA - 2016/12/29
PB - Mendeleev Communications
SP - 82-84
IS - 1
VL - 27
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2016_Abzianidze,
author = {Victoria Vadimovna Abzianidze and Ksenia P Bolshakova and Daria Stanislavovna Prokofieva and Alexander Olegovich Berestetskiy and Victor Anatol'evich Kuznetsov and Yury Georgievich Trishin},
title = {Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity},
journal = {Mendeleev Communications},
year = {2016},
volume = {27},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.01.026},
number = {1},
pages = {82--84},
doi = {10.1016/j.mencom.2017.01.026}
}
MLA
Cite this
MLA Copy
Abzianidze, Victoria Vadimovna, et al. “Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity.” Mendeleev Communications, vol. 27, no. 1, Dec. 2016, pp. 82-84. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2017.01.026.

Abstract

The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of exocyclic C=C bond and N–OMe group in such compounds is suggested to be a factor in their antitumor activity.

References

1.
10.1016/j.mencom.2017.01.026_sbref0005a
Wall
Cancer Res., 1995
3.
Morozova N.G., Timofeev G.A., Timakova A.A., Shmendel E.V., Kubasova T.S., Tyutyunnik L.L., Markova A.A., Maslov M.A., Shtil A.A.
Mendeleev Communications, 2015
4.
Rakitina T.V., Zeifman A.A., Novikov F.N., Stroganov O.V., Stroylov V.S., Svitanko I.V., Frank-Kamenetskii A., Chilov G.G.
Mendeleev Communications, 2015
5.
Phaeosphaeride A, an Inhibitor of STAT3-Dependent Signaling Isolated from an Endophytic Fungus
Maloney K.N., Hao W., Xu J., Gibbons J., Hucul J., Roll D., Brady S.F., Schroeder F.C., Clardy J.
Organic Letters, 2006
6.
10.1016/j.mencom.2017.01.026_bib0020
Abzianidze
Acta Crystallogr., 2015
7.
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
Pommier Y., Leo E., Zhang H., Marchand C.
Chemistry & Biology, 2010
9.
Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential
Abzianidze V.V., Prokofieva D.S., Chisty L.A., Bolshakova K.P., Berestetskiy A.O., Panikorovskii T.L., Bogachenkov A.S., Holder A.A.
Bioorganic and Medicinal Chemistry Letters, 2015
11.
Catalysis of the specific michael addition : The example of acrylate acceptors
Cabral J., Laszlo P., Mahé L., Montaufier M., Randriamahefa S.L.
Tetrahedron Letters, 1989