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Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease

Sergey Aleksandrovich Kozin 1
Sergey Aleksandrovich Kozin
, 
Vladimir Aleksandrovich Mitkevich 1
Vladimir Aleksandrovich Mitkevich
, 
Alexander Aleksandrovich Makarov 1
Alexander Aleksandrovich Makarov
10.1016/j.mencom.2016.07.001
Published 2016-07-07
Focus article , Volume 26, Issue 4, 269-275
31
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Kozin S. A., Mitkevich V. A., Makarov A. A. Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease // Mendeleev Communications. 2016. Vol. 26. No. 4. pp. 269-275.
GOST all authors (up to 50) Copy
Kozin S. A., Mitkevich V. A., Makarov A. A. Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease // Mendeleev Communications. 2016. Vol. 26. No. 4. pp. 269-275.
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TY - JOUR
DO - 10.1016/j.mencom.2016.07.001
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2016.07.001
TI - Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease
T2 - Mendeleev Communications
AU - Kozin, Sergey Aleksandrovich
AU - Mitkevich, Vladimir Aleksandrovich
AU - Makarov, Alexander Aleksandrovich
PY - 2016
DA - 2016/07/07
PB - Mendeleev Communications
SP - 269-275
IS - 4
VL - 26
ER -
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@article{2016_Kozin,
author = {Sergey Aleksandrovich Kozin and Vladimir Aleksandrovich Mitkevich and Alexander Aleksandrovich Makarov},
title = {Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease},
journal = {Mendeleev Communications},
year = {2016},
volume = {26},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2016.07.001},
number = {4},
pages = {269--275},
doi = {10.1016/j.mencom.2016.07.001}
}
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Kozin, Sergey Aleksandrovich, et al. “Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease.” Mendeleev Communications, vol. 26, no. 4, Jul. 2016, pp. 269-275. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2016.07.001.
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Abstract

Recent data about structure, interaction with biometals, aggregation state, proteolysis by angiotensin converting enzyme, neurotoxicity and amyloidogenicity of amyloid-β containing isoaspartate 7 (isoAsp7-Aβ) in comparison with intact amyloid-β are summarized. Possible role of isoAsp7-Aβ as a prospective biomarker for molecular diagnostics and drug target in anti-amyloid therapy of Alzheimer's disease is discussed.

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