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Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment

Victor Pavlovich Krasnov 1
Victor Pavlovich Krasnov
, 
Dmitry Andreevich Gruzdev 1
Dmitry Andreevich Gruzdev
, 
Evgeny Nikolaevich Chulakov 1
Evgeny Nikolaevich Chulakov
, 
Alexey Yur'evich Vigorov 1
Alexey Yur'evich Vigorov
, 
Vera Vasil'evna Musiyak 1
Vera Vasil'evna Musiyak
, 
Tatyana Victorovna Matveeva 1
Tatyana Victorovna Matveeva
, 
Andrey Arturovich Tumashov 1
Andrey Arturovich Tumashov
, 
Galina L'vovna Levit 1
Galina L'vovna Levit
, 
10.1016/j.mencom.2015.11.003
Published 2015-11-09
Communication , Volume 25, Issue 6, 412-414
11
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Krasnov V. P. et al. Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment // Mendeleev Communications. 2015. Vol. 25. No. 6. pp. 412-414.
GOST all authors (up to 50) Copy
Krasnov V. P., Gruzdev D. A., Chulakov E. N., Vigorov A. Y., Musiyak V. V., Matveeva T. V., Tumashov A. A., Levit G. L., Charushin V. N. Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment // Mendeleev Communications. 2015. Vol. 25. No. 6. pp. 412-414.
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TY - JOUR
DO - 10.1016/j.mencom.2015.11.003
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.11.003
TI - Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment
T2 - Mendeleev Communications
AU - Krasnov, Victor Pavlovich
AU - Gruzdev, Dmitry Andreevich
AU - Chulakov, Evgeny Nikolaevich
AU - Vigorov, Alexey Yur'evich
AU - Musiyak, Vera Vasil'evna
AU - Matveeva, Tatyana Victorovna
AU - Tumashov, Andrey Arturovich
AU - Levit, Galina L'vovna
AU - Charushin, Valery Nikolaevich
PY - 2015
DA - 2015/11/09
PB - Mendeleev Communications
SP - 412-414
IS - 6
VL - 25
ER -
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@article{2015_Krasnov,
author = {Victor Pavlovich Krasnov and Dmitry Andreevich Gruzdev and Evgeny Nikolaevich Chulakov and Alexey Yur'evich Vigorov and Vera Vasil'evna Musiyak and Tatyana Victorovna Matveeva and Andrey Arturovich Tumashov and Galina L'vovna Levit and Valery Nikolaevich Charushin},
title = {Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment},
journal = {Mendeleev Communications},
year = {2015},
volume = {25},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.11.003},
number = {6},
pages = {412--414},
doi = {10.1016/j.mencom.2015.11.003}
}
MLA
Cite this
MLA Copy
Krasnov, Victor Pavlovich, et al. “Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment.” Mendeleev Communications, vol. 25, no. 6, Nov. 2015, pp. 412-414. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.11.003.

Abstract

Novel conjugates of purine and 2-aminopurine linked with heterocyclic amines, including chiral derivatives of 3,4-dihydro-2H-[1,4]benzoxazine, 3,4-dihydro-2H-[1,4]benzothiazine and 1,2,3,4-tetrahydroquinoline, by 6-aminohexanoyl fragment at the 6-position of purine moiety were obtained. For this purpose, replacement of the chlorine atom in 2-amino-6-chloropurine or 6-chloropurine by direct nucleophilic substitution reaction with 6-aminohexanamides or the coupling of 6-(purin-6-ylamino)-6-hexanoic acid with nitrogen heterocycles were used.

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