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Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro

Tatiana Vladimirovna Rakitina 1, 2
Tatiana Vladimirovna Rakitina
, 
Alexey A Zeifman 3
Alexey A Zeifman
, 
Fedor Nikolaevich Novikov 3
Fedor Nikolaevich Novikov
, 
Oleg Valentinovich Stroganov 3
Oleg Valentinovich Stroganov
, 
Viktor Sergeevich Stroylov 3
Viktor Sergeevich Stroylov
, 
Igor Svitanko 3, 4
Igor Svitanko
, 
Anastasia Frank-Kamenetskii 1
Anastasia Frank-Kamenetskii
, 
Ghermes Grigor'evich Chilov 3
Ghermes Grigor'evich Chilov
10.1016/j.mencom.2015.09.016
Published 2015-09-10
Communication , Volume 25, Issue 5, 364-366
3
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Rakitina T. V. et al. Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro // Mendeleev Communications. 2015. Vol. 25. No. 5. pp. 364-366.
GOST all authors (up to 50) Copy
Rakitina T. V., Zeifman A. A., Novikov F. N., Stroganov O. V., Stroylov V. S., Svitanko I., Frank-Kamenetskii A., Chilov G. G. Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro // Mendeleev Communications. 2015. Vol. 25. No. 5. pp. 364-366.
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TY - JOUR
DO - 10.1016/j.mencom.2015.09.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.09.016
TI - Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro
T2 - Mendeleev Communications
AU - Rakitina, Tatiana Vladimirovna
AU - Zeifman, Alexey A
AU - Novikov, Fedor Nikolaevich
AU - Stroganov, Oleg Valentinovich
AU - Stroylov, Viktor Sergeevich
AU - Svitanko, Igor
AU - Frank-Kamenetskii, Anastasia
AU - Chilov, Ghermes Grigor'evich
PY - 2015
DA - 2015/09/10
PB - Mendeleev Communications
SP - 364-366
IS - 5
VL - 25
ER -
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@article{2015_Rakitina,
author = {Tatiana Vladimirovna Rakitina and Alexey A Zeifman and Fedor Nikolaevich Novikov and Oleg Valentinovich Stroganov and Viktor Sergeevich Stroylov and Igor Svitanko and Anastasia Frank-Kamenetskii and Ghermes Grigor'evich Chilov},
title = {Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro},
journal = {Mendeleev Communications},
year = {2015},
volume = {25},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.09.016},
number = {5},
pages = {364--366},
doi = {10.1016/j.mencom.2015.09.016}
}
MLA
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MLA Copy
Rakitina, Tatiana Vladimirovna, et al. “Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro.” Mendeleev Communications, vol. 25, no. 5, Sep. 2015, pp. 364-366. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.09.016.

Abstract

Six novel potential PARP1 inhibitors were identified by means of substructure search and molecular docking into PAPR1 active site; one compound (STK970217) potentiated the cytotoxicity of doxorubicin in hepatocellular carcinoma HepG2 cells being non-cytotoxic as a single agent, while three other identified compounds inhibited the growth of HepG2 cells both individually and in combination with doxorubicin.

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