Home / Publications / A practical synthesis of deuterium-labeled cefuroxime

A practical synthesis of deuterium-labeled cefuroxime

Dawei Liang 1
Dawei Liang
, 
Yueqiu Wang 1
Yueqiu Wang
, 
Yanyan Wang 2
Yanyan Wang
1 Department of Pharmacy & Medical Laboratory, Ya'an Vocational College, Ya'an, China
2 Department of Traditional Chinese Medicine, Lianyungang TCM Branch of Jiangsu Union Technical Institute, Lianyungang, P. R. China
10.1016/j.mencom.2015.07.005
Published 2015-07-08
Communication , Volume 25, Issue 4, 252-253
8
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Liang D., Wang Y., Wang Y. A practical synthesis of deuterium-labeled cefuroxime // Mendeleev Communications. 2015. Vol. 25. No. 4. pp. 252-253.
GOST all authors (up to 50) Copy
Liang D., Wang Y., Wang Y. A practical synthesis of deuterium-labeled cefuroxime // Mendeleev Communications. 2015. Vol. 25. No. 4. pp. 252-253.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2015.07.005
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.07.005
TI - A practical synthesis of deuterium-labeled cefuroxime
T2 - Mendeleev Communications
AU - Liang, Dawei
AU - Wang, Yueqiu
AU - Wang, Yanyan
PY - 2015
DA - 2015/07/08
PB - Mendeleev Communications
SP - 252-253
IS - 4
VL - 25
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2015_Liang,
author = {Dawei Liang and Yueqiu Wang and Yanyan Wang},
title = {A practical synthesis of deuterium-labeled cefuroxime},
journal = {Mendeleev Communications},
year = {2015},
volume = {25},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.07.005},
number = {4},
pages = {252--253},
doi = {10.1016/j.mencom.2015.07.005}
}
MLA
Cite this
MLA Copy
Liang, Dawei, et al. “A practical synthesis of deuterium-labeled cefuroxime.” Mendeleev Communications, vol. 25, no. 4, Jul. 2015, pp. 252-253. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.07.005.

Abstract

The deuterium-labeled cefuroxime, an internal standard drug, has been achieved in 5 steps from the commercially available methoxyl-d3-amine hydrochloride with 14% overall yield and chemical purity > 99%, the isotope purity was over 98%.

References

1.
Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury
Kossmann T., Hans V., Stocker R., Imhof H.-., Joos B., Trentz O., Morganti-Kossmann M.C.
Journal of Antimicrobial Chemotherapy, 1996
2.
Staphylococcus aureus Meningitis: Experience with Cefuroxime Treatment During a 16 Year Period in a Danish Region
Nørgaard M., Gudmundsdottir G., Larsen C.S., Schønheyder H.C.
Scandinavian Journal of Infectious Diseases, 2003
3.
10.1016/j.mencom.2015.07.005_bib0015
Pichichero
J. Fam. Practice, 2006
4.
Cefuroxime Pharmacokinetics in Pediatric Cardiovascular Surgery Patients Undergoing Cardiopulmonary Bypass
Knoderer C.A., Saft S.A., Walker S.G., Rodefeld M.D., Turrentine M.W., Brown J.W., Healy D.P., Sowinski K.M.
Journal of Cardiothoracic and Vascular Anesthesia, 2011
5.
E. Siviero, W. Cabri and D. M. Terrassan, US Patent WO 2000/071547, 2000 (Chem. Abstr., 2000, 134, 17346).
6.
P. B. Deshpande, G.K. Das, P.N. Deshpande, R. Chandrasekaran, P. Ramar and J. M. R. Jeyakumar, US Patent WO 2004/0082560, 2004 (Chem. Abstr., 2004, 140, 357115).
7.
P. Kremminger, US Patent WO 2002/020532, 2002 (Chem. Abstr., 2002, 136, 236835).
8.
W. Cabri, E. Siviero and P. L. Darverlo, US Patent WO 2001/007443, 2001 (Chem. Abstr., 2001, 134, 115798).
9.
J. K. Somani, I. Bhushan and H. Sen, US Patent WO 2000/056286, 2000 (Chem. Abstr., 2000, 133, 256835).
10.
Synthetic Approach to Gain Insight into Antigenic Determinants of Cephalosporins: In Vitro Studies of Chemical Structure−IgE Molecular Recognition Relationships
Montañez M.I., Mayorga C., Torres M.J., Ariza A., Blanca M., Perez-Inestrosa E.
Chemical Research in Toxicology, 2011
11.
Liquid chromatography/electrospray tandem mass spectrometry method for the determination of cefuroxime in human plasma: Application to a pharmacokinetic study
Partani P., Gurule S., Khuroo A., Monif T., Bhardwaj S.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2010