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Synthesis of gem-bisphosphonates with (3-aryl-4,5-dihydroisoxazol-5-yl)methylamino moiety

10.1016/j.mencom.2015.05.027
Published 2015-04-28
Communication , Volume 25, Issue 3, 234-235
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Brel V. K. Synthesis of gem-bisphosphonates with (3-aryl-4,5-dihydroisoxazol-5-yl)methylamino moiety // Mendeleev Communications. 2015. Vol. 25. No. 3. pp. 234-235.
GOST all authors (up to 50) Copy
Brel V. K. Synthesis of gem-bisphosphonates with (3-aryl-4,5-dihydroisoxazol-5-yl)methylamino moiety // Mendeleev Communications. 2015. Vol. 25. No. 3. pp. 234-235.
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TY - JOUR
DO - 10.1016/j.mencom.2015.05.027
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.05.027
TI - Synthesis of gem-bisphosphonates with (3-aryl-4,5-dihydroisoxazol-5-yl)methylamino moiety
T2 - Mendeleev Communications
AU - Brel, Valery Kuzmich
PY - 2015
DA - 2015/04/28
PB - Mendeleev Communications
SP - 234-235
IS - 3
VL - 25
ER -
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@article{2015_Brel,
author = {Valery Kuzmich Brel},
title = {Synthesis of gem-bisphosphonates with (3-aryl-4,5-dihydroisoxazol-5-yl)methylamino moiety},
journal = {Mendeleev Communications},
year = {2015},
volume = {25},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.05.027},
number = {3},
pages = {234--235},
doi = {10.1016/j.mencom.2015.05.027}
}
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Brel, Valery Kuzmich. “Synthesis of gem-bisphosphonates with (3-aryl-4,5-dihydroisoxazol-5-yl)methylamino moiety.” Mendeleev Communications, vol. 25, no. 3, Apr. 2015, pp. 234-235. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.05.027.

Abstract

Three-component reaction between N-allyl-N-methylamine, triethyl orthoformate and diethyl phosphite affords N-[bis(diethoxyphosphoryl)methyl]-N-methyl-3-arylprop-3-en-1-amine whose cycloaddition with nitrile N-oxides gives 5-{N-[bis(diethoxyphosphoryl)methyl]-N-methylamino}methyl-4,5-dihydroisoxazoles.

References

3.
Bisphosphonates: From Bench to Bedside
RUSSELL R.G.
Annals of the New York Academy of Sciences, 2006
5.
Discovery of pyrazoles as novel FPR1 antagonists
Morley A.D., Cook A., King S., Roberts B., Lever S., Weaver R., MacDonald C., Unitt J., Fagura M., Phillips T., Lewis R., Wenlock M.
Bioorganic and Medicinal Chemistry Letters, 2011
6.
Bisphosphonates: Mechanisms of Action
Fleisch H.
Endocrine Reviews, 1998
7.
T. M. Balashova and I. D. Kolpakova, in Metody polucheniya khimicheskikh reaktivov i preparatov (Methods of Obtaining of Chemical Reagents and Preparations), 1973, vol. 25, p. 11 (in Russian).
8.
Herstellung von 1-Aminoalkan-1,1-diphosphons�uren
Pl�ger W., Schindler N., Wollmann K., Worms K.H.
Zeitschrift fur Anorganische und Allgemeine Chemie, 1972
9.
Syntheses of N-phenylaminomethylenediphosphonic and -diphosphinic acids and their derivatives
Prishchenko A.A., Livantsov M.V., Novikova O.P., Livantsova L.I.
Russian Journal of General Chemistry, 2009
10.
10.1016/j.mencom.2015.05.027_sbref0040a
Maier
Elem., 1981
11.
Synthesis and Evaluation of (Piperidinomethylene)bis(phosphonic acid) Derivatives as Anti-osteoporosis Agents.
MIMURA M., HAYASHIDA M., NOMIYAMA K., IKEGAMI S., IIDA Y., TAMURA M., HIYAMA Y., OHISHI Y.
Chemical and Pharmaceutical Bulletin, 2011
12.
Nitrile Oxides
Jäger V., Colinas P.A.
Cumulative Index of Heterocyclic Systems, 2002
14.
Asymmetric 1,3-dipolar cycloadditions of nitrile oxides using simple chiral auxiliaries
Olsson T., Stern K., Sundell S.
Journal of Organic Chemistry, 1988
15.
Synthesis of (Z) and (E) α-alkenyl phosphonic acid derivatives of purines and pyrimidines
Lazrek H.B., Rochdi A., Khaider H., Barascut J.-., Imbach J.-., Balzarini J., Witvrouw M., Pannecouque C., De Clercq E.
Tetrahedron, 1998