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Cobra cytotoxins: determinants of antibacterial activity

Peter Victorovich Dubovskii 1
Peter Victorovich Dubovskii
, 
Olga Valentinovna Vorontsova 1, 2
Olga Valentinovna Vorontsova
, 
Yuri Nikolaevich Utkin 1
Yuri Nikolaevich Utkin
, 
Aleksandr Sergeevich Arsen'ev 1
Aleksandr Sergeevich Arsen'ev
, 
Roman Gerbertovich Efremov 1, 3
Roman Gerbertovich Efremov
, 
Alexey Valeryevich Feofanov 1, 2
Alexey Valeryevich Feofanov
10.1016/j.mencom.2015.01.026
Published 2014-12-26
Communication , Volume 25, Issue 1, 70-71
7
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Dubovskii P. V. et al. Cobra cytotoxins: determinants of antibacterial activity // Mendeleev Communications. 2014. Vol. 25. No. 1. pp. 70-71.
GOST all authors (up to 50) Copy
Dubovskii P. V., Vorontsova O. V., Utkin Y. N., Arsen'ev A. S., Efremov R. G., Feofanov A. V. Cobra cytotoxins: determinants of antibacterial activity // Mendeleev Communications. 2014. Vol. 25. No. 1. pp. 70-71.
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TY - JOUR
DO - 10.1016/j.mencom.2015.01.026
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.01.026
TI - Cobra cytotoxins: determinants of antibacterial activity
T2 - Mendeleev Communications
AU - Dubovskii, Peter Victorovich
AU - Vorontsova, Olga Valentinovna
AU - Utkin, Yuri Nikolaevich
AU - Arsen'ev, Aleksandr Sergeevich
AU - Efremov, Roman Gerbertovich
AU - Feofanov, Alexey Valeryevich
PY - 2014
DA - 2014/12/26
PB - Mendeleev Communications
SP - 70-71
IS - 1
VL - 25
ER -
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@article{2014_Dubovskii,
author = {Peter Victorovich Dubovskii and Olga Valentinovna Vorontsova and Yuri Nikolaevich Utkin and Aleksandr Sergeevich Arsen'ev and Roman Gerbertovich Efremov and Alexey Valeryevich Feofanov},
title = {Cobra cytotoxins: determinants of antibacterial activity},
journal = {Mendeleev Communications},
year = {2014},
volume = {25},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.01.026},
number = {1},
pages = {70--71},
doi = {10.1016/j.mencom.2015.01.026}
}
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Cite this
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Dubovskii, Peter Victorovich, et al. “Cobra cytotoxins: determinants of antibacterial activity.” Mendeleev Communications, vol. 25, no. 1, Dec. 2014, pp. 70-71. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2015.01.026.

Abstract

The investigation of antibacterial activity of three-finger cobra cytotoxins towards Gram-negative and Gram-positive bacteria showed no activity against the former species, whereas M. luteus from the latter ones was the most susceptible to cytotoxins. A correlation was revealed between this activity and hydrophobicity of the toxins (HTL scores), total charge and its distribution over the toxin molecule: the absence of Glu-16 residue and the presence of positively charged residues (Lys30/His31) in the tip of the loop 2.

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