Home / Publications / Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues

Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues

Dmitrii Veniaminovich Shishov 1
Dmitrii Veniaminovich Shishov
, 
Evgeniya Vladimirovna Nurieva 1
Evgeniya Vladimirovna Nurieva
, 
Nikolai Serafimovich Zefirov 1
Nikolai Serafimovich Zefirov
, 
Alexandra Valerievna Mamaeva 1
Alexandra Valerievna Mamaeva
, 
Ol'ga Nikolaevna Zefirova 1, 2
Ol'ga Nikolaevna Zefirova
10.1016/j.mencom.2014.11.021
Published 2014-10-30
Communication , Volume 24, Issue 6, 370-371
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Shishov D. V. et al. Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues // Mendeleev Communications. 2014. Vol. 24. No. 6. pp. 370-371.
GOST all authors (up to 50) Copy
Shishov D. V., Nurieva E. V., Zefirov N. S., Mamaeva A. V., Zefirova O. N. Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues // Mendeleev Communications. 2014. Vol. 24. No. 6. pp. 370-371.
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TY - JOUR
DO - 10.1016/j.mencom.2014.11.021
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2014.11.021
TI - Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues
T2 - Mendeleev Communications
AU - Shishov, Dmitrii Veniaminovich
AU - Nurieva, Evgeniya Vladimirovna
AU - Zefirov, Nikolai Serafimovich
AU - Mamaeva, Alexandra Valerievna
AU - Zefirova, Ol'ga Nikolaevna
PY - 2014
DA - 2014/10/30
PB - Mendeleev Communications
SP - 370-371
IS - 6
VL - 24
ER -
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@article{2014_Shishov,
author = {Dmitrii Veniaminovich Shishov and Evgeniya Vladimirovna Nurieva and Nikolai Serafimovich Zefirov and Alexandra Valerievna Mamaeva and Ol'ga Nikolaevna Zefirova},
title = {Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues},
journal = {Mendeleev Communications},
year = {2014},
volume = {24},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2014.11.021},
number = {6},
pages = {370--371},
doi = {10.1016/j.mencom.2014.11.021}
}
MLA
Cite this
MLA Copy
Shishov, Dmitrii Veniaminovich, et al. “Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues.” Mendeleev Communications, vol. 24, no. 6, Oct. 2014, pp. 370-371. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2014.11.021.

Abstract

Hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien-8-one was synthesized from 1-benzyloxy-4-bromo-2-methoxybenzene in six steps comprising Corey–Chaykovsky epoxidation and Friedel–Crafts intramolecular cyclization. The crystal structure of the benzyl-protected derivative of the target compound was determined by X-ray analysis.

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