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Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers

Andrey Vasil'evich Filippov 1, 2
Andrey Vasil'evich Filippov
, 
Oleg Nikolaevich Antzutkin 2, 3
Oleg Nikolaevich Antzutkin
10.1016/j.mencom.2013.11.003
Published 2013-10-30
Communication , Volume 23, Issue 6, 316-318
3
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Filippov A. V., Antzutkin O. N. Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers // Mendeleev Communications. 2013. Vol. 23. No. 6. pp. 316-318.
GOST all authors (up to 50) Copy
Filippov A. V., Antzutkin O. N. Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers // Mendeleev Communications. 2013. Vol. 23. No. 6. pp. 316-318.
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TY - JOUR
DO - 10.1016/j.mencom.2013.11.003
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2013.11.003
TI - Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers
T2 - Mendeleev Communications
AU - Filippov, Andrey Vasil'evich
AU - Antzutkin, Oleg Nikolaevich
PY - 2013
DA - 2013/10/30
PB - Mendeleev Communications
SP - 316-318
IS - 6
VL - 23
ER -
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@article{2013_Filippov,
author = {Andrey Vasil'evich Filippov and Oleg Nikolaevich Antzutkin},
title = {Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers},
journal = {Mendeleev Communications},
year = {2013},
volume = {23},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2013.11.003},
number = {6},
pages = {316--318},
doi = {10.1016/j.mencom.2013.11.003}
}
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Filippov, Andrey Vasil'evich, and Oleg Nikolaevich Antzutkin. “Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers.” Mendeleev Communications, vol. 23, no. 6, Oct. 2013, pp. 316-318. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2013.11.003.

Abstract

The effect of added Alzheimer's Aβ(1-40) peptide of the wild type on the lateral diffusion of lipids in macroscopically oriented bilayers of ‘raft’ compositions [a mixture of dioleoylphosphatidylcholine (DOPC), sphingomyelin (SM) and cholesterol (CHOL)] was studied by an NMR-diffusion technique. In homogeneous bilayers, diffusion coefficients decrease, while they change differently in liquid ordered and in liquid disordered phases at varied concentrations of CHOL; this was explained by the decreased maximum solubility of CHOL in phospholipids in the presence of Aβ(1-40) peptide.

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