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Cross-linked Polymeric Micelles based on Block Ionomer Complexes

Jong Oh KIm 1
Jong Oh KIm
, 
Thiruganesh Ramasamy 1
Thiruganesh Ramasamy
, 
Chul Soon Yong 1
Chul Soon Yong
, 
Natalia Vladimirovna Nukolova 2, 3
Natalia Vladimirovna Nukolova
, 
Tatiana K Bronich 4
Tatiana K Bronich
, 
Alexander Viktorovich Kabanov 2, 5
Alexander Viktorovich Kabanov
10.1016/j.mencom.2013.07.001
Published 2013-07-11
Focus article , Volume 23, Issue 4, 179-186
27
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KIm J. O. et al. Cross-linked Polymeric Micelles based on Block Ionomer Complexes // Mendeleev Communications. 2013. Vol. 23. No. 4. pp. 179-186.
GOST all authors (up to 50) Copy
KIm J. O., Ramasamy T., Yong C. S., Nukolova N. V., Bronich T. K., Kabanov A. V. Cross-linked Polymeric Micelles based on Block Ionomer Complexes // Mendeleev Communications. 2013. Vol. 23. No. 4. pp. 179-186.
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TY - JOUR
DO - 10.1016/j.mencom.2013.07.001
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2013.07.001
TI - Cross-linked Polymeric Micelles based on Block Ionomer Complexes
T2 - Mendeleev Communications
AU - KIm, Jong Oh
AU - Ramasamy, Thiruganesh
AU - Yong, Chul Soon
AU - Nukolova, Natalia Vladimirovna
AU - Bronich, Tatiana K
AU - Kabanov, Alexander Viktorovich
PY - 2013
DA - 2013/07/11
PB - Mendeleev Communications
SP - 179-186
IS - 4
VL - 23
ER -
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@article{2013_KIm,
author = {Jong Oh KIm and Thiruganesh Ramasamy and Chul Soon Yong and Natalia Vladimirovna Nukolova and Tatiana K Bronich and Alexander Viktorovich Kabanov},
title = {Cross-linked Polymeric Micelles based on Block Ionomer Complexes},
journal = {Mendeleev Communications},
year = {2013},
volume = {23},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2013.07.001},
number = {4},
pages = {179--186},
doi = {10.1016/j.mencom.2013.07.001}
}
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KIm, Jong Oh, et al. “Cross-linked Polymeric Micelles based on Block Ionomer Complexes.” Mendeleev Communications, vol. 23, no. 4, Jul. 2013, pp. 179-186. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2013.07.001.
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Abstract

Polymeric micelles formed as a result of the self-assembly of block copolymers constitute an important class of supramolecular structures that attracted attention as drug carriers in drug delivery and nanomedicine. Chemical stabilization of the polymeric micelles by introducing cross-links between block copolymer chains can increase stability and prevent premature disintegration of these micelles in the body. The cross-linking strategy has been also applied to a special class of polymeric micelles formed by block copolymers with ionic and nonionic water-soluble segments (block ionomers) that are electrostatically coupled with oppositely charged species. Such polyion complex micelles (also termed block ionomer complexes) have high colloidal stability due to steric repulsion of their corona and often assume a spherical core–shell morphology. These species are currently actively researched for the delivery of various low molecular weight drugs and protein or nucleic acid-based therapeutics. This paper highlights recent advances in the development of cross-linked polymeric micelles, the physicochemical aspects of the formation and behavior of various block ionomer complexes, the strategies for the cross-linking of core and shell parts of the micelles, and the advantages and major challenges in their biomedical applications.

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