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Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold

, 
Alexey Igorevich Ilovaisky 1
Alexey Igorevich Ilovaisky
, 
Valentina Mikhailovna Merkulova 1
Valentina Mikhailovna Merkulova
, 
Tatiana Aleksandrovna Zaimovskaya 2
Tatiana Aleksandrovna Zaimovskaya
, 
Gennady Ivanovich Nikishin 1
Gennady Ivanovich Nikishin
10.1016/j.mencom.2012.05.010
Published 2012-04-27
Communication , Volume 22, Issue 3, 143-144
39
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Elinson M. N. et al. Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold // Mendeleev Communications. 2012. Vol. 22. No. 3. pp. 143-144.
GOST all authors (up to 50) Copy
Elinson M. N., Ilovaisky A. I., Merkulova V. M., Zaimovskaya T. A., Nikishin G. I. Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold // Mendeleev Communications. 2012. Vol. 22. No. 3. pp. 143-144.
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TY - JOUR
DO - 10.1016/j.mencom.2012.05.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.05.010
TI - Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold
T2 - Mendeleev Communications
AU - Elinson, Michail Nikolaevich
AU - Ilovaisky, Alexey Igorevich
AU - Merkulova, Valentina Mikhailovna
AU - Zaimovskaya, Tatiana Aleksandrovna
AU - Nikishin, Gennady Ivanovich
PY - 2012
DA - 2012/04/27
PB - Mendeleev Communications
SP - 143-144
IS - 3
VL - 22
ER -
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@article{2012_Elinson,
author = {Michail Nikolaevich Elinson and Alexey Igorevich Ilovaisky and Valentina Mikhailovna Merkulova and Tatiana Aleksandrovna Zaimovskaya and Gennady Ivanovich Nikishin},
title = {Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold},
journal = {Mendeleev Communications},
year = {2012},
volume = {22},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.05.010},
number = {3},
pages = {143--144},
doi = {10.1016/j.mencom.2012.05.010}
}
MLA
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Elinson, Michail Nikolaevich, et al. “Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold.” Mendeleev Communications, vol. 22, no. 3, Apr. 2012, pp. 143-144. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.05.010.

Abstract

Thermal non-catalytic reaction of isatin, cyclic CH-acids and malononitrile in water or alcohols affords substituted spirooxindoles in 90–97% yields.

References

1.
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Evans B.E., Rittle K.E., Bock M.G., DiPardo R.M., Freidinger R.M., Whitter W.L., Lundell G.F., Veber D.F., Anderson P.S., Chang R.S., Lotti V.J., Cerino D.J., Chen T.B., Kling P.J., Kunkel K.A., et. al.
Journal of Medicinal Chemistry, 1988
3.
From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’
de Sa Alves F., Barreiro E., Manssour Fraga C.
Mini-Reviews in Medicinal Chemistry, 2009
4.
Silva J.F., Garden S.J., Pinto A.C.
Journal of the Brazilian Chemical Society, 2001
5.
(b) S. N. Pandeya, S. Smitha, M. Jyoti and S. K. Sridhar, Acta Pharm., 2005, 55, 27;
6.
(c) D. Shiram, T.R. Bal and P. Yogeeswari, J. Pharm. Pharm. Sci., 2005, 8, 565;
7.
Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives.
Karalı N., Gürsoy A., Kandemirli F., Shvets N., Kaynak F.B., Özbey S., Kovalishyn V., Dimoglo A.
Bioorganic and Medicinal Chemistry, 2007
10.
Screening of cytotoxic activities of Strychnos alkaloids (methods and results).
Leclercq J., De Pauw-Gillet M., Bassleer R., Angenot L.
Journal of Ethnopharmacology, 1986
12.
A. A. Shestopalov, L.A. Rodinovskaya, A.M. Shestopalov and V. P. Litvinov, Izv. Akad. Nauk, Ser. Khim., 2005, 968.(Russ. Chem. Bull., Int. Ed., 2005, 54, 992).
16.
Synthesis of fused 2′-amino-3′-R-spiro-[indole-3,4′-pyran]-2(1H)-ones
Shemchuk L.A., Chernykh V.P., Red’kin R.G.
Russian Journal of Organic Chemistry, 2008
17.
10.1016/j.mencom.2012.05.010_bib0070
Hari
Synthesis, 2010
21.
Demchuk D.V., Elinson M.N., Nikishin G.I.
Mendeleev Communications, 2011
22.
Rates of Ionization of Pseudo Acids.1 IV. Relation between Rates and Equilibria
Pearson R.G., Dillon R.L.
Journal of the American Chemical Society, 1953