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Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties

Ol'ga Nikolaevna Zefirova 1, 2
Ol'ga Nikolaevna Zefirova
, 
Tatiana Yuryevna Baranova 1
Tatiana Yuryevna Baranova
, 
Konstantin Alexandrovich Lyssenko 3
Konstantin Alexandrovich Lyssenko
, 
Nikolay Alekseevich Zefirov 1
Nikolay Alekseevich Zefirov
, 
Nikolai Vasil'evich Zyk 1
Nikolai Vasil'evich Zyk
, 
Pavel Mikhailovich Vassiliev 4
Pavel Mikhailovich Vassiliev
, 
Dmitrii Sergeevich Yakovlev 4
Dmitrii Sergeevich Yakovlev
, 
Alexander Alekseevich Spasov 4
Alexander Alekseevich Spasov
10.1016/j.mencom.2012.03.007
Published 2012-02-27
Communication , Volume 22, Issue 2, 75-77
6
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Zefirova O. N. et al. Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties // Mendeleev Communications. 2012. Vol. 22. No. 2. pp. 75-77.
GOST all authors (up to 50) Copy
Zefirova O. N., Baranova T. Y., Lyssenko K. A., Zefirov N. A., Zyk N. V., Vassiliev P. M., Yakovlev D. S., Spasov A. A. Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties // Mendeleev Communications. 2012. Vol. 22. No. 2. pp. 75-77.
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TY - JOUR
DO - 10.1016/j.mencom.2012.03.007
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.03.007
TI - Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties
T2 - Mendeleev Communications
AU - Zefirova, Ol'ga Nikolaevna
AU - Baranova, Tatiana Yuryevna
AU - Lyssenko, Konstantin Alexandrovich
AU - Zefirov, Nikolay Alekseevich
AU - Zyk, Nikolai Vasil'evich
AU - Vassiliev, Pavel Mikhailovich
AU - Yakovlev, Dmitrii Sergeevich
AU - Spasov, Alexander Alekseevich
PY - 2012
DA - 2012/02/27
PB - Mendeleev Communications
SP - 75-77
IS - 2
VL - 22
ER -
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@article{2012_Zefirova,
author = {Ol'ga Nikolaevna Zefirova and Tatiana Yuryevna Baranova and Konstantin Alexandrovich Lyssenko and Nikolay Alekseevich Zefirov and Nikolai Vasil'evich Zyk and Pavel Mikhailovich Vassiliev and Dmitrii Sergeevich Yakovlev and Alexander Alekseevich Spasov},
title = {Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties},
journal = {Mendeleev Communications},
year = {2012},
volume = {22},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.03.007},
number = {2},
pages = {75--77},
doi = {10.1016/j.mencom.2012.03.007}
}
MLA
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MLA Copy
Zefirova, Ol'ga Nikolaevna, et al. “Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties.” Mendeleev Communications, vol. 22, no. 2, Feb. 2012, pp. 75-77. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.03.007.

Abstract

The synthesis of conformationally restricted serotonin analogues based on indol derivatives annelated with bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane moieties is described. The configuration of the amino group in a structure is proved on the basis of X-ray data for N- [(9R)-2-methoxy-6,7,8,9,10,11-hexahydro-5H-6,10-methanocycloocta[b]indol-9-yl]acetamide. The ex vivo testing results of four products to 5HT3 serotonin receptors are presented.

References

1.
Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues
Zefirova O.N., Baranova T.Y., Ivanova A.A., Ivanov A.A., Zefirov N.S.
Bioorganic Chemistry, 2011
2.
Baranova T.Y., Averina N.V., Zyk N.V., Zefirov N.S., Lyssenko K.A., Antipin M.Y., Zefirova O.N.
Mendeleev Communications, 2009
3.
10.1016/j.mencom.2012.03.007_bib0015
Baranova
Zh. Org. Khim., 2007
4.
Molecular and crystal structure of indole derivatives fused with substituted bicyclo[3.3.1]nonane
Zefirova O.N., Potekhin K.A., Touchin A.I., Averina N.V., Baranova T.Y., Zyk N.V., Zefirov N.S.
Structural Chemistry, 2007
6.
P. M. Vassiliev, L.V. Naumenko and A. A. Spasov, Abstr. IV Int. Symp. Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMPTI-2007), Moscow, 2007, PO-56, p. 126.
7.
Binding Interactions of Antagonists with 5‐Hydroxytryptamine3AReceptor Models
Maksay G., Bikádi Z., Simonyi M.
Journal of Receptor and Signal Transduction Research, 2003
8.
Synthesis and Chiroptical Properties of Methanocycloocta[b]indoles
Butkus E., Berg U., Malinauskienė J., Sandström J.
Journal of Organic Chemistry, 2000
9.
RICONThe Computer Program for the Quantitative Investigations of Cyclic Organic Molecule Conformations
Zotov A.Y., Palyulin V.A., Zefirov N.S.
Journal of Chemical Information and Computer Sciences, 1997
11.
Regulatory molecules for the 5-HT3 receptor ion channel gating system.
Yoshida S., Watanabe T., Sato Y.
Bioorganic and Medicinal Chemistry, 2007