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Rational design and synthesis of novel Syk-kinase inhibitors

Alexey A Zeifman 1
Alexey A Zeifman
, 
Ilya Yur'evich Titov 1, 2
Ilya Yur'evich Titov
, 
Igor Svitanko 2
Igor Svitanko
, 
Tatiana Vladimirovna Rakitina 3, 4
Tatiana Vladimirovna Rakitina
, 
Aleksey Valer'evich Lipkin 4, 5
Aleksey Valer'evich Lipkin
, 
Viktor Sergeevich Stroylov 1, 2
Viktor Sergeevich Stroylov
, 
Oleg Valentinovich Stroganov 1, 2
Oleg Valentinovich Stroganov
, 
Fedor Nikolaevich Novikov 1
Fedor Nikolaevich Novikov
, 
Ghermes Grigor'evich Chilov 1, 2
Ghermes Grigor'evich Chilov
10.1016/j.mencom.2012.03.006
Published 2012-02-27
Communication , Volume 22, Issue 2, 73-74
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Zeifman A. A. et al. Rational design and synthesis of novel Syk-kinase inhibitors // Mendeleev Communications. 2012. Vol. 22. No. 2. pp. 73-74.
GOST all authors (up to 50) Copy
Zeifman A. A., Titov I. Y., Svitanko I., Rakitina T. V., Lipkin A. V., Stroylov V. S., Stroganov O. V., Novikov F. N., Chilov G. G. Rational design and synthesis of novel Syk-kinase inhibitors // Mendeleev Communications. 2012. Vol. 22. No. 2. pp. 73-74.
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TY - JOUR
DO - 10.1016/j.mencom.2012.03.006
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.03.006
TI - Rational design and synthesis of novel Syk-kinase inhibitors
T2 - Mendeleev Communications
AU - Zeifman, Alexey A
AU - Titov, Ilya Yur'evich
AU - Svitanko, Igor
AU - Rakitina, Tatiana Vladimirovna
AU - Lipkin, Aleksey Valer'evich
AU - Stroylov, Viktor Sergeevich
AU - Stroganov, Oleg Valentinovich
AU - Novikov, Fedor Nikolaevich
AU - Chilov, Ghermes Grigor'evich
PY - 2012
DA - 2012/02/27
PB - Mendeleev Communications
SP - 73-74
IS - 2
VL - 22
ER -
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@article{2012_Zeifman,
author = {Alexey A Zeifman and Ilya Yur'evich Titov and Igor Svitanko and Tatiana Vladimirovna Rakitina and Aleksey Valer'evich Lipkin and Viktor Sergeevich Stroylov and Oleg Valentinovich Stroganov and Fedor Nikolaevich Novikov and Ghermes Grigor'evich Chilov},
title = {Rational design and synthesis of novel Syk-kinase inhibitors},
journal = {Mendeleev Communications},
year = {2012},
volume = {22},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.03.006},
number = {2},
pages = {73--74},
doi = {10.1016/j.mencom.2012.03.006}
}
MLA
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MLA Copy
Zeifman, Alexey A., et al. “Rational design and synthesis of novel Syk-kinase inhibitors.” Mendeleev Communications, vol. 22, no. 2, Feb. 2012, pp. 73-74. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2012.03.006.

Abstract

Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC50 = 230±10 nM

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