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1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy

Igor Viktorovich Vystorop 1
Igor Viktorovich Vystorop
, 
Nina Petrovna Konovalova 1
Nina Petrovna Konovalova
, 
Tatiana Evgen'evna Sashenkova 1
Tatiana Evgen'evna Sashenkova
, 
Elena Nikolaevna Berseneva 1
Elena Nikolaevna Berseneva
, 
Alexander Vladimirovich Chernyak 1
Alexander Vladimirovich Chernyak
, 
Boris Sergeevich Fedorov 1
Boris Sergeevich Fedorov
, 
Remir Grigorevich Kostyanovsky 2
Remir Grigorevich Kostyanovsky
10.1016/j.mencom.2011.09.002
Published 2011-09-14
Communication , Volume 21, Issue 5, 239-241
5
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Vystorop I. V. et al. 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy // Mendeleev Communications. 2011. Vol. 21. No. 5. pp. 239-241.
GOST all authors (up to 50) Copy
Vystorop I. V., Konovalova N. P., Sashenkova T. E., Berseneva E. N., Chernyak A. V., Fedorov B. S., Kostyanovsky R. G. 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy // Mendeleev Communications. 2011. Vol. 21. No. 5. pp. 239-241.
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TY - JOUR
DO - 10.1016/j.mencom.2011.09.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.09.002
TI - 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy
T2 - Mendeleev Communications
AU - Vystorop, Igor Viktorovich
AU - Konovalova, Nina Petrovna
AU - Sashenkova, Tatiana Evgen'evna
AU - Berseneva, Elena Nikolaevna
AU - Chernyak, Alexander Vladimirovich
AU - Fedorov, Boris Sergeevich
AU - Kostyanovsky, Remir Grigorevich
PY - 2011
DA - 2011/09/14
PB - Mendeleev Communications
SP - 239-241
IS - 5
VL - 21
ER -
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@article{2011_Vystorop,
author = {Igor Viktorovich Vystorop and Nina Petrovna Konovalova and Tatiana Evgen'evna Sashenkova and Elena Nikolaevna Berseneva and Alexander Vladimirovich Chernyak and Boris Sergeevich Fedorov and Remir Grigorevich Kostyanovsky},
title = {1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy},
journal = {Mendeleev Communications},
year = {2011},
volume = {21},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.09.002},
number = {5},
pages = {239--241},
doi = {10.1016/j.mencom.2011.09.002}
}
MLA
Cite this
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Vystorop, Igor Viktorovich, et al. “1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy.” Mendeleev Communications, vol. 21, no. 5, Sep. 2011, pp. 239-241. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.09.002.

Abstract

Condensation of glycine and dl-alanine hydroxamic acids with 1-methyl-4-piperidone regioselectively gave the corresponding titled spiro piperidine hydroxyimidazolidinones capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophosphamide.

References

1.
Targeting the DNA Damage Response in Cancer
Ljungman M.
Chemical Reviews, 2009
3.
Pharmacologic and Chemical Adjuvants in Tumor Virotherapy
Alvarez-Breckenridge C., Kaur B., Chiocca E.A.
Chemical Reviews, 2009
5.
10.1016/j.mencom.2011.09.002_bib0010_2
Fazary
Med. J. Islamic Acad. Sci., 2001
6.
Hydroxamic acids as pharmacological agents.
Muri E., Nieto M., Sindelar R., Williamson J.
Current Medicinal Chemistry, 2002
8.
Hydroxamic Acids − An Intriguing Family of Enzyme Inhibitors and Biomedical Ligands
Marmion C., Griffith D., Nolan K.
European Journal of Inorganic Chemistry, 2004
9.
Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance
Konovalova N.P., Goncharova S.A., Volkova L.M., Rajewskaya T.A., Eremenko L.T., Korolev A.M.
Nitric Oxide - Biology and Chemistry, 2003
10.
Vystorop I.V., Lyssenko K.A., Kostyanovsky R.G.
Mendeleev Communications, 2002
11.
10.1016/j.mencom.2011.09.002_bib0035
Vystorop
Izv. Akad. Nauk, Ser. Khim., 2000
12.
10.1016/j.mencom.2011.09.002_bib0040
Vystorop
Izv. Akad. Nauk, Ser. Khim., 2010
14.
10.1016/j.mencom.2011.09.002_bib0045_2
Feliu
ARKIVOC, 2007
15.
D. H. Williams and I. Fleming, Spectroscopic Methods in Organic Chemistry, 5th edn., McGraw-Hill Co., London, 1995.
16.
10.1016/j.mencom.2011.09.002_bib0055
Shchukin
Khim. Geterotsikl. Soedin., 1990
17.
449. Hydroxamic acids. Part II. The synthesis and structure of cyclic hydroxamic acids from pyridine and quinoline
Cunningham K.G., Newbold G.T., Spring F.S., Stark J.
Journal of the Chemical Society (Resumed), 1949
18.
Eksperimental’naya otsenka protivorakovykh preparatov v SSSR i SShA (Experimental Evaluation of Anticancer Drugs in USSR and USA), eds. Z. Sof’ina, A. Syrkin, A. Goldin and A. Klyain, Meditsina, Moscow, 1980.(in Russian).