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The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids

Alexey Yu Sukhorukov 1
Alexey Yu Sukhorukov
, 
Svetlana O Andryushkevich 2
Svetlana O Andryushkevich
, 
Ghermes Grigor'evich Chilov 1
Ghermes Grigor'evich Chilov
, 
Alexey A Zeifman 1
Alexey A Zeifman
, 
Igor Svitanko 1, 2
Igor Svitanko
, 
Sema Leibovich Ioffe 1
Sema Leibovich Ioffe
10.1016/j.mencom.2011.07.002
Published 2011-07-01
Communication , Volume 21, Issue 4, 183-185
6
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Sukhorukov A. Yu. et al. The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids // Mendeleev Communications. 2011. Vol. 21. No. 4. pp. 183-185.
GOST all authors (up to 50) Copy
Sukhorukov A. Yu., Andryushkevich S. O., Chilov G. G., Zeifman A. A., Svitanko I., Ioffe S. L. The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids // Mendeleev Communications. 2011. Vol. 21. No. 4. pp. 183-185.
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TY - JOUR
DO - 10.1016/j.mencom.2011.07.002
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.07.002
TI - The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids
T2 - Mendeleev Communications
AU - Sukhorukov, Alexey Yu
AU - Andryushkevich, Svetlana O
AU - Chilov, Ghermes Grigor'evich
AU - Zeifman, Alexey A
AU - Svitanko, Igor
AU - Ioffe, Sema Leibovich
PY - 2011
DA - 2011/07/01
PB - Mendeleev Communications
SP - 183-185
IS - 4
VL - 21
ER -
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@article{2011_Sukhorukov,
author = {Alexey Yu Sukhorukov and Svetlana O Andryushkevich and Ghermes Grigor'evich Chilov and Alexey A Zeifman and Igor Svitanko and Sema Leibovich Ioffe},
title = {The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids},
journal = {Mendeleev Communications},
year = {2011},
volume = {21},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.07.002},
number = {4},
pages = {183--185},
doi = {10.1016/j.mencom.2011.07.002}
}
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MLA Copy
Sukhorukov, Alexey Yu., et al. “The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids.” Mendeleev Communications, vol. 21, no. 4, Jul. 2011, pp. 183-185. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.07.002.

Abstract

Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1, new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4H-1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.

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