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Biologically important nucleosides: modern trends in biotechnology and application

Igor Alexandrovich Mikhailopulo 1
Igor Alexandrovich Mikhailopulo
, 
Anatoly Ivanovich Miroshnikov 2
Anatoly Ivanovich Miroshnikov
10.1016/j.mencom.2011.03.001
Published 2011-03-10
Focus article , Volume 21, Issue 2, 57-68
97
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Mikhailopulo I. A., Miroshnikov A. I. Biologically important nucleosides: modern trends in biotechnology and application // Mendeleev Communications. 2011. Vol. 21. No. 2. pp. 57-68.
GOST all authors (up to 50) Copy
Mikhailopulo I. A., Miroshnikov A. I. Biologically important nucleosides: modern trends in biotechnology and application // Mendeleev Communications. 2011. Vol. 21. No. 2. pp. 57-68.
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TY - JOUR
DO - 10.1016/j.mencom.2011.03.001
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.03.001
TI - Biologically important nucleosides: modern trends in biotechnology and application
T2 - Mendeleev Communications
AU - Mikhailopulo, Igor Alexandrovich
AU - Miroshnikov, Anatoly Ivanovich
PY - 2011
DA - 2011/03/10
PB - Mendeleev Communications
SP - 57-68
IS - 2
VL - 21
ER -
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@article{2011_Mikhailopulo,
author = {Igor Alexandrovich Mikhailopulo and Anatoly Ivanovich Miroshnikov},
title = {Biologically important nucleosides: modern trends in biotechnology and application},
journal = {Mendeleev Communications},
year = {2011},
volume = {21},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.03.001},
number = {2},
pages = {57--68},
doi = {10.1016/j.mencom.2011.03.001}
}
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Mikhailopulo, Igor Alexandrovich, and Anatoly Ivanovich Miroshnikov. “Biologically important nucleosides: modern trends in biotechnology and application.” Mendeleev Communications, vol. 21, no. 2, Mar. 2011, pp. 57-68. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2011.03.001.
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Abstract

Modern trends in biotechnology of nucleosides of biochemical and medicinal importance are outlined. Emphasis is made on the enzymatic transformations within the general chemo-enzymatic approach to the synthesis of nucleosides. Some aspects of (i) the functioning of enzymes of nucleic acid metabolism of interest as biocatalysts, (ii) the transglycosylation reaction using sugar modified nucleosides as donors of carbohydrate residues and heterocyclic bases as acceptors catalyzed by nucleoside phosphorylases and N-deoxyribosyltransferases, (iii) the miscellaneous transformations employing D-pentofuranose 5-phosphates or α-D-pentofuranose 1-phosphates as universal glycosylatig substrates, (iv) the retrosynthesis, and (v) the one-pot transformation of D-pentoses into nucleosides are considered.

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