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Enzymatic resolution of (±)-venlafaxine

Konstantin Aleksandrovich Kochetkov 1
Konstantin Aleksandrovich Kochetkov
, 
Maria Aleksandrovna Galkina 1
Maria Aleksandrovna Galkina
, 
Oleg M Galkin 1
Oleg M Galkin
10.1016/j.mencom.2010.11.003
Published 2010-11-02
Communication , Volume 20, Issue 6, 314-315
9
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Kochetkov K. A., Galkina M. A., Galkin O. M. Enzymatic resolution of (±)-venlafaxine // Mendeleev Communications. 2010. Vol. 20. No. 6. pp. 314-315.
GOST all authors (up to 50) Copy
Kochetkov K. A., Galkina M. A., Galkin O. M. Enzymatic resolution of (±)-venlafaxine // Mendeleev Communications. 2010. Vol. 20. No. 6. pp. 314-315.
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TY - JOUR
DO - 10.1016/j.mencom.2010.11.003
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.11.003
TI - Enzymatic resolution of (±)-venlafaxine
T2 - Mendeleev Communications
AU - Kochetkov, Konstantin Aleksandrovich
AU - Galkina, Maria Aleksandrovna
AU - Galkin, Oleg M
PY - 2010
DA - 2010/11/02
PB - Mendeleev Communications
SP - 314-315
IS - 6
VL - 20
ER -
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@article{2010_Kochetkov,
author = {Konstantin Aleksandrovich Kochetkov and Maria Aleksandrovna Galkina and Oleg M Galkin},
title = {Enzymatic resolution of (±)-venlafaxine},
journal = {Mendeleev Communications},
year = {2010},
volume = {20},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.11.003},
number = {6},
pages = {314--315},
doi = {10.1016/j.mencom.2010.11.003}
}
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Kochetkov, Konstantin Aleksandrovich, et al. “Enzymatic resolution of (±)-venlafaxine.” Mendeleev Communications, vol. 20, no. 6, Nov. 2010, pp. 314-315. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.11.003.

Abstract

Lipase-catalyzed acylation of the racemic venlafaxine with vinyl acetate in chloroform at 20°C gives its (R)-enantiomer and (S)-acetate, the ee value of the latter being>99%.

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