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Small rings in focus: recent routes to cyclopropylgroup containing carbo- and heterocycles

Armin de Meijere 1
Armin de Meijere
, 
Sergei Ivanovich Kozhushkov 1
Sergei Ivanovich Kozhushkov
10.1016/j.mencom.2010.11.001
Published 2010-11-02
Focus article , Volume 20, Issue 6, 301-311
19
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de Meijere A., Kozhushkov S. I. Small rings in focus: recent routes to cyclopropylgroup containing carbo- and heterocycles // Mendeleev Communications. 2010. Vol. 20. No. 6. pp. 301-311.
GOST all authors (up to 50) Copy
de Meijere A., Kozhushkov S. I. Small rings in focus: recent routes to cyclopropylgroup containing carbo- and heterocycles // Mendeleev Communications. 2010. Vol. 20. No. 6. pp. 301-311.
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TY - JOUR
DO - 10.1016/j.mencom.2010.11.001
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.11.001
TI - Small rings in focus: recent routes to cyclopropylgroup containing carbo- and heterocycles
T2 - Mendeleev Communications
AU - de Meijere, Armin
AU - Kozhushkov, Sergei Ivanovich
PY - 2010
DA - 2010/11/02
PB - Mendeleev Communications
SP - 301-311
IS - 6
VL - 20
ER -
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@article{2010_de Meijere,
author = {Armin de Meijere and Sergei Ivanovich Kozhushkov},
title = {Small rings in focus: recent routes to cyclopropylgroup containing carbo- and heterocycles},
journal = {Mendeleev Communications},
year = {2010},
volume = {20},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.11.001},
number = {6},
pages = {301--311},
doi = {10.1016/j.mencom.2010.11.001}
}
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de Meijere, Armin, and Sergei Ivanovich Kozhushkov. “Small rings in focus: recent routes to cyclopropylgroup containing carbo- and heterocycles.” Mendeleev Communications, vol. 20, no. 6, Nov. 2010, pp. 301-311. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.11.001.
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Abstract

The development of modern synthetic methodologies and advanced analytical tools during almost 130 years after the first preparation of a three-membered carbocycle made it possible that several unusual and initially exotic hydrocarbons with cyclopropane rings have become common laboratory reagents. These hydrocarbons not only exhibit unusual physical and thermochemical properties: as the cyclopropane ring is a functional group itself, all of these molecules and their derivatives constitute oligofunctional building blocks, and they can be involved in transformations of the initially formed intermediates or products in sequential reactions or multistep cascade reactions. In many cases, this results in the formation of carbo- and heterocycles with cyclopropyl substituents on a framework or cyclopropyl groups incorporated in a structure. Some of these products exhibit significant biological activities, the cyclopropyl groups exerting favorable or beneficial effects in a number of senses.

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