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Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures

Dmitry Nikolaevich Platonov 1
Dmitry Nikolaevich Platonov
, 
Galina Petrovna Okonnishnikova 1
Galina Petrovna Okonnishnikova
, 
10.1016/j.mencom.2010.03.006
Published 2010-03-05
Communication , Volume 20, Issue 2, 83-85
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Platonov D. N., Okonnishnikova G. P., Tomilov Y. V. Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures // Mendeleev Communications. 2010. Vol. 20. No. 2. pp. 83-85.
GOST all authors (up to 50) Copy
Platonov D. N., Okonnishnikova G. P., Tomilov Y. V. Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures // Mendeleev Communications. 2010. Vol. 20. No. 2. pp. 83-85.
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TY - JOUR
DO - 10.1016/j.mencom.2010.03.006
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.03.006
TI - Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures
T2 - Mendeleev Communications
AU - Platonov, Dmitry Nikolaevich
AU - Okonnishnikova, Galina Petrovna
AU - Tomilov, Yury Vasil'evich
PY - 2010
DA - 2010/03/05
PB - Mendeleev Communications
SP - 83-85
IS - 2
VL - 20
ER -
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@article{2010_Platonov,
author = {Dmitry Nikolaevich Platonov and Galina Petrovna Okonnishnikova and Yury Vasil'evich Tomilov},
title = {Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures},
journal = {Mendeleev Communications},
year = {2010},
volume = {20},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.03.006},
number = {2},
pages = {83--85},
doi = {10.1016/j.mencom.2010.03.006}
}
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Platonov, Dmitry Nikolaevich, et al. “Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures.” Mendeleev Communications, vol. 20, no. 2, Mar. 2010, pp. 83-85. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2010.03.006.

Keywords

1,2-dihydroisoquinolines,cyclization

Abstract

Original methods were developed for the synthesis of 1,2-dihydroisoquinoline derivatives by means of the cyclization of N-substituted hexamethoxycarbonyl-3-propenylpyridin-2-ones either upon action of bases or directly by reaction of hepta-(methoxycarbonyl)cycloheptatrienyl potassium with primary amines.

References

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H. Tieckelmann, in Pyridine and Its Derivatives, ed. R. A. Abramovitch, Interscience, New York, 1974, vol. 14, part 3, ch. 12.
2.
Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones
Matsui T., Sugiura T., Nakai H., Iguchi S., Shigeoka S., Takada H., Odagaki Y., Nagao Y., Ushio Y.
Journal of Medicinal Chemistry, 1992
5.
Synthesis of 2'-Cyanomethy1-2-biphenylcarboxylic Acid
KOBAYASHI S., KITAMURA K., MIURA A., FUKUDA M., KIHARA M., AZEKAWA M.
Chemical and Pharmaceutical Bulletin, 2011