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A new approach to densely functionalised azepines and dihydroazepines

Nina Alekseevna Nedolya 1
Nina Alekseevna Nedolya
, 
Ol'ga Anatol'evna Tarasova 1
Ol'ga Anatol'evna Tarasova
, 
Alexander Ivanovich Albanov 1
Alexander Ivanovich Albanov
, 
Ol'ga Gennad'evna Volostnykh 1
Ol'ga Gennad'evna Volostnykh
, 
Lambert Brandsma 2
Lambert Brandsma
, 
Boris Aleksandrovich Trofimov 1
Boris Aleksandrovich Trofimov
10.1016/j.mencom.2008.05.018
Published 2008-05-14
Communication , Volume 18, Issue 3, 164-166
19
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Nedolya N. A. et al. A new approach to densely functionalised azepines and dihydroazepines // Mendeleev Communications. 2008. Vol. 18. No. 3. pp. 164-166.
GOST all authors (up to 50) Copy
Nedolya N. A., Tarasova O. A., Albanov A. I., Volostnykh O. G., Brandsma L., Trofimov B. A. A new approach to densely functionalised azepines and dihydroazepines // Mendeleev Communications. 2008. Vol. 18. No. 3. pp. 164-166.
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TY - JOUR
DO - 10.1016/j.mencom.2008.05.018
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2008.05.018
TI - A new approach to densely functionalised azepines and dihydroazepines
T2 - Mendeleev Communications
AU - Nedolya, Nina Alekseevna
AU - Tarasova, Ol'ga Anatol'evna
AU - Albanov, Alexander Ivanovich
AU - Volostnykh, Ol'ga Gennad'evna
AU - Brandsma, Lambert
AU - Trofimov, Boris Aleksandrovich
PY - 2008
DA - 2008/05/14
PB - Mendeleev Communications
SP - 164-166
IS - 3
VL - 18
ER -
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@article{2008_Nedolya,
author = {Nina Alekseevna Nedolya and Ol'ga Anatol'evna Tarasova and Alexander Ivanovich Albanov and Ol'ga Gennad'evna Volostnykh and Lambert Brandsma and Boris Aleksandrovich Trofimov},
title = {A new approach to densely functionalised azepines and dihydroazepines},
journal = {Mendeleev Communications},
year = {2008},
volume = {18},
publisher = {Mendeleev Communications},
month = {May},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2008.05.018},
number = {3},
pages = {164--166},
doi = {10.1016/j.mencom.2008.05.018}
}
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Nedolya, Nina Alekseevna, et al. “A new approach to densely functionalised azepines and dihydroazepines.” Mendeleev Communications, vol. 18, no. 3, May. 2008, pp. 164-166. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2008.05.018.

Abstract

The easy transformation of 2-(1-alkoxyethoxy)-N-(1-methylethylidene)-1-(methylsulfanyl)-1,3-butadien-1-amines (2-aza-1,3,5-trienes) into 3-(1-alkoxyethoxy)-7-methyl-2-(methylsulfanyl)-4,5-dihydro-3H-azepines and 6-(1-alkoxyethoxy)-2-methyl-3H-azepines has been found to proceed under the action of ButOK in THF–DMSO or THF; the mild acidic hydrolysis of 4,5-dihydro-3H-azepines gives hydroxy derivatives.

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